TGFβ suppresses cytotoxicity
نویسندگان
چکیده
منابع مشابه
Dasatinib suppresses in vitro natural killer cell cytotoxicity.
ferential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet (http://genetics.plosjournals.org/). 2005;1:e28. Accessed January 8, 2008. 5. Pronk CJH, Rossi DJ, Månsson R, et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell. 2007;1:428-442. 6. Chambers SM, Boles NC, Lin KK, et al. H...
متن کاملSMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGFβ-independent manner.
UNLABELLED SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin thr...
متن کاملR-Spondin1/LGR5 Activates TGFβ Signaling and Suppresses Colon Cancer Metastasis.
Leucine-rich repeat containing G-protein-coupled receptor 5 (LGR5), an intestinal stem cell marker, is known to exhibit tumor suppressor activity in colon cancer, the mechanism of which is not understood. Here we show that R-spondin 1 (RSPO1)/LGR5 directly activates TGFβ signaling cooperatively with TGFβ type II receptor in colon cancer cells, enhancing TGFβ-mediated growth inhibition and stres...
متن کاملLiberating TGFβ
Stem cell side show B efore scientists can harness heart stem cells to repair damage to the organ, they have to pin down the elusive cells. On page 329, Oyama et al. bolster the case for a group of cells known as side population cells, showing for the fi rst time that they home in on injured heart muscle and differentiate into all the types of cardiac cells in vivo. Previous research has turned...
متن کاملNotch and TGFβ
Cell signals integral to the tumor microenvironment influence cancer progression. Tumor-associated myeloid cells secrete pro-tumorigenic agents including, but not limited to, the potent cytokine transforming growth factor β (TGFβ). We have discovered a network of extrinsic signals including delta-like 4 (Dll4), Notch and TGFβ, linking malignant cells and tumor-infiltrating myeloid cells, a nexu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2006
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1771